what is the significance of efflux pumps in drug resistance ?

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What is the significance of efflux pumps in drug resistance?
RND family efflux pumps have tripartite organization and are the major contributors to intrinsic antibiotic resistance in GNB, which expel a broad spectrum of antibiotics and biocides, including fluoroquinolones, β-lactams, tetracycline and linezolid.
 

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